A good old cup of coffee is the go-to panacea for everyday low energy and fatigue. 54% of Americans over the age of 18 drink coffee every day. Americans average 3.1 cups a day and the average size of a cup is 9 oz. Coffee’s caffeine jolt can temporarily boost alertness, perk up performance, and possibly even improve concentration. But caffeine is a drug, and as with any drug, there are right ways and wrong ways to use it. Caffeine can be worrisome for people with high blood pressure, diabetes, and osteoporosis. Plus, caffeine can interact poorly with some common medications, and it can worsen insomnia, anxiety, and heartburn. There are several disorders in which fatigue is pronounced, and they typically trace their pathology back to mitochondrial dysfunction. Vitamin D deficiency—which is common worldwide—is a principal cause of such fatigue and myopathy. In 1976, the American Egg Board created the slogan “The Incredible, Edible Egg.” This slogan became a pre-Internet meme of sorts, garnering what we would now refer to as viral status. Somewhere along the line, people developed a disdain for eggs due to concerns about cholesterol. However, studies on dietary lipids and CVD incidence have shown that dietary cholesterol is not an independent risk factor for heart disease. Today, eggs remain both incredible and, well, edible. Eggs provide a nutrient-dense source of energy from protein and fat, approximately 75 kcal per large egg, as well as several B vitamins, including thiamin, riboflavin, folate, B12, and B6, which are required to produce energy by the body.